Human Transglutaminase 4/TGM4 (AAC50516.1) VersaClone cDNA

Name: Human Transglutaminase 4/TGM4 (AAC50516.1) VersaClone cDNA
Brand: R&D Systems
SKU: RDC3144
Price: 675 USD
Availability: InStock

R&D Systems | Catalog # RDC3144

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Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

AAC50516.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Transglutaminase 4/TGM4

The principal activity of transglutaminases (TGMs) is to catalyze the Ca²⁺-dependent formation of an isopeptide bond between the gamma-carboxamide group of a glutaminyl residue and the epsilon-amino group of a lysyl residue. TGMs can also catalyze the attachment of polyamines to the gamma-carboxamide group of a glutaminyl residue and the deamidation of glutaminyl residues. Several TGMs have also been shown to possess protein disulfide isomerase activity. Protein aggregates in the brain are a common feature of a number of neurodegenerative diseases, such as Alzheimerâ€™s, Parkinsonâ€™s, and Huntingtonâ€™s. Recent reports indicate that TGMs contribute to the formation of protein aggregates in the brain by crosslinking proteins such as Huntingtin and ataxins.

TGM4 is known as the prostate-specific transglutaminase because it is expressed and secreted exclusively by the prostate gland.6 In rodents, TGM4 is required for the formation of the copulatory plug and sperm antigenicity, but its function in humans is not understood. The expression of TGM4 is primarily regulated by retinoic acid and to a lesser degree by androgens.

Alternate Names

Fibrinoligase, TGM4, TGP

Entrez Gene IDs

7047 (Human); 331046 (Mouse); 64679 (Rat)

Gene Symbol

TGM4

UniProt

AAC50516.1

Additional Transglutaminase 4/TGM4 Products

Product Documents for Human Transglutaminase 4/TGM4 (AAC50516.1) VersaClone cDNA

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Product Specific Notices for Human Transglutaminase 4/TGM4 (AAC50516.1) VersaClone cDNA

For research use only

Related Research Areas

Extracellular Matrix Molecules

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