Trappin-2 is the human member of the trappin gene family that contains SLPI (1). Trappin-2 consists of an N-terminal transglutaminase substrate domain (residues 23‑60) and a C-terminal four-disulfide core or whey acidic protein (WAP) domain (residues 72‑117). Elafin or ESI (elastase-specific inhibitor) and SKALP (skin-derived anti-leucoproteinase) are alternative names for Trappin-2 and reflect its protease targets. However, elafin and SKALP sometimes correspond only to the processed form that contains the C-terminal WAP domain of the molecule, which can be isolated naturally. The recombinant human Trappin-2 corresponds to the full‑length form (residues 23‑117), which migrates as two protein bands under SDS-PAGE due to an unidentified mechanism. In addition to its ability to inhibit human neutrophil elastase, it can also be used as a substrate for transglutaminases.
Human Trappin‑2/Elafin Alexa Fluor™ Plus 594‑conjugated Antibody
R&D Systems | Catalog # AF1747AFP594
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human Trappin‑2/Elafin Alexa Fluor™ Plus 594‑conjugated Antibody
ELISA Capture (Matched Antibody Pair)
Immunoprecipitation
Western Blot
Neutralization
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: Trappin-2/Elafin
References
- Schalkwijk, J. et al. (1999) Biochem. J. 340:569.
Long Name
Alternate Names
Entrez Gene IDs
Gene Symbol
UniProt
Additional Trappin-2/Elafin Products
Product Documents for Human Trappin‑2/Elafin Alexa Fluor™ Plus 594‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Human Trappin‑2/Elafin Alexa Fluor™ Plus 594‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
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- Cellular Response to Hypoxia Protocols
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