Hydroxychloroquine sulfate

Catalog # Availability Size / Price Qty
5648/10
5648/50
Cat.No. 5648 - Hydroxychloroquine sulfate | C18H28ClN3O5S | CAS No. 747-36-4
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Description: Autophagy inhibitor; also TLR9 inhibitor

Chemical Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate

Purity: ≥99%

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Biological Activity

Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Also inhibits TLR9.

Technical Data

M.Wt:
433.95
Formula:
C18H28ClN3O5S
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
747-36-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.
    Lee HO, Mustafa A, Hudes GR, Kruger WD.
    PLoS One.
  2. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
    Lamphier et al.
    Mol.Pharmacol., 2014;85:429

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