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Potent AMPK inhibitor; also BMP type I receptor inhibitor
Potent inhibitor of SERCA ATPase
Promotes assembly and inhibits disassembly of microtubules
Selective and high affinity cathepsin D inhibitor
mTOR inhibitor; Immunosuppressant
H+-ATPase (vacuolar) inhibitor
Activator of LKB1/AMPK; antidiabetic agent
Anti-inflammatory glucocorticoid
mTOR inhibitor; immunosuppressant
Antibiotic; GlcNAc phosphotransferase inhibitor
Antimalarial; inhibits apoptosis and autophagy
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Histone deacetylase inhibitor
Potent and selective mTOR inhibitor
Highly selective P2X1 antagonist
Cathepsin inhibitor; interferes with autolysosomal digestion
Protein kinase C inhibitor
Disrupts protein translocation to Golgi
p53 inhibitor. Also aryl hydrocarbon receptor agonist
Inositol monophosphatase inhibitor
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
HMG-CoA reductase inhibitor
H+-ATPase (vacuolar) inhibitor
DNA-methylating antitumor agent
Class III PI 3-kinase inhibitor; also inhibits autophagy
STAT3 inhibitor; also inhibits mTORC1 signaling
Positive regulator of autophagy
Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Autophagy inhibitor; also TLR9 inhibitor
Potent and selective p97 ATPase (VCP) allosteric inhibitor
Inhibitor of PI 3-kinase, mTOR and DNA-PK
Broad spectrum ion channel blocker; antiarrhythmic
Inhibitor of neuronal NaV channels; anticonvulsant
Potent and selective mTOR inhibitor
Selective and reversible p97 ATPase inhibitor
p97 ATPase (VCP) inhibitor
Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor
ATP-competitive inhibitor of p97 ATPase
mTOR inhibitor; antitumor
Potent and selective Foxo1 inhibitor; orally bioavailable