BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0
cell cycle arrest in MLL-fusion leukemic cell lines in vitro
values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo
. Enhances differentiation of human iPSC into megakaryocytes.
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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Dawson et al.
Scalable generation of universal platelets from human induced pluripotent stem cells.
Feng et al.
Stem Cell Reports, 2014;3:817
The citations listed below are publications that use Tocris products. Selected citations for I-BET 151 dihydrochloride include:
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