IDE 1

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4015/50
IDE 1 | CAS No. 1160927-48-9 | Compounds for Stem Cell Differentiation
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Description: Induces definitive endoderm formation in mouse and human ESCs

Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.

This compound is mixture of E/Z isomers.

Technical Data

M.Wt:
306.31
Formula:
C15H18N2O5
Solubility:
Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1160927-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purpose under license from Harvard University.
Other Product-Specific Information:
  • This compound is mixture of E/Z isomers

Product Datasheets

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Reconstitution Calculator

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Citations for IDE 1

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