Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Biological ActivityInduces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.
This compound is mixture of E/Z isomers.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
- This compound is mixture of E/Z isomers
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
Cell Stem Cell, 2009;4(4):348-58.
Using small molecules to great effect in stem cell differentiation.
Cell Stem Cell, 2009;4:373
Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
Filby et al.
Stem Cell Res.Ther., 2011;2:16
Citations for IDE 1
The citations listed below are publications that use Tocris products. Selected citations for IDE 1 include:
2 Citations: Showing 1 - 2
Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol.
Authors: Xu Et al.
Stem Cell Res 2015;6:193
Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.
Authors: Kearns Et al.
J Cell Mol Med 2013;11:1003
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