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IDE 1 | CAS No. 1160927-48-9 | Compounds for Stem Cell Differentiation
1 Image
Description: Induces definitive endoderm formation in mouse and human ESCs

Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

IDE 1 is an induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.

This compound is mixture of E/Z isomers.

Technical Data

Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purpose under license from Harvard University.
Other Product-Specific Information:
  • This compound is mixture of E/Z isomers

Background References

  1. Using small molecules to great effect in stem cell differentiation.
    Cell Stem Cell, 2009;4:373
  2. Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
    Filby et al.
    Stem Cell Res.Ther., 2011;2:16
  3. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009-04-03;4(4):348-58.

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Citations for IDE 1

The citations listed below are publications that use Tocris products. Selected citations for IDE 1 include:

3 Citations: Showing 1 - 3


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