Catalog Number: 4015
Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Biological Activity
Induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.

This compound is mixture of E/Z isomers.

Technical Data
  • M.Wt:
    306.31
  • Formula:
    C15H18N2O5
  • Solubility:
    Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1160927-48-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purpose under license from Harvard University.
Other Product-Specific Information:
  • This compound is mixture of E/Z isomers
Background References
  1. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Borowiak M, Maehr R, Chen S et al.
    Cell Stem Cell.
  2. Using small molecules to great effect in stem cell differentiation.
    Zaret
    Cell Stem Cell, 2009;4:373
  3. Stimulation of activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
    Filby et al.
    Stem Cell Res.Ther., 2011;2:16
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IDE 1 include:

2 Citations: Showing 1 - 2
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  1. Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol.
    Authors: Xu Et al.
    Stem Cell Res 2015;6:193
  2. Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.
    Authors: Kearns Et al.
    J Cell Mol Med 2013;11:1003

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