Induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50
= 125 nM). Thought to activate the TGF-β
signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purpose under license from Harvard University.
Other Product-Specific Information:
- This compound is mixture of E/Z isomers
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Borowiak M, Maehr R, Chen S et al.
Cell Stem Cell.
Using small molecules to great effect in stem cell differentiation.
Cell Stem Cell, 2009;4:373
Stimulation of activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
Filby et al.
Stem Cell Res.Ther., 2011;2:16
The citations listed below are publications that use Tocris products. Selected citations for IDE 1 include:
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