Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Biological Activity Induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.
This compound is mixture of E/Z isomers.
Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO
Store at +4°C
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