IKK 16

Catalog # Availability Size / Price Qty
2539/10
2539/50
IKK 16 | CAS No. 1186195-62-9 | IkB Kinase Inhibitors
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Description: Selective inhibitor of IKK

Chemical Name: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (7)
Reviews (1)

Biological Activity

Selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Technical Data

M.Wt:
520.09
Formula:
C28H29N5OS.HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
1186195-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK.
    Waelchli et al.
    Bioorg.Med.Chem.Lett., 2006;16:108

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IKK 16 blocks LPA-mediated COX-2 expression
By Anonymous on 12/13/2018
Species: Human

Human osteosarcoma cells were incubated with 5 μM IKK 16 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. IKK 16 abolished LPA-induced COX-2 expression


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