IKK 16

Tocris Bioscience | Catalog # 2539

Selective inhibitor of IKK
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of IKK
View all IkB Kinase Inhibitors »

Product Description

IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Product Specifications for IKK 16

Molecular Weight

520.09

Formula

C28H29N5OS.HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

CAS Number

1186195-62-9

PubChem ID

56972179

InChI Key

XFVDIVQCZWDBCW-UHFFFAOYSA-N

SMILES

Cl.O=C(N1CCC(CC1)N1CCCC1)C1=CC=C(NC2=NC=CC(=N2)C2=CC3=CC=CC=C3S2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26 50
DMSO 26 50

Preparing Stock Solutions for IKK 16

The following data is based on the product molecular weight 520.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.85 mL 19.23 mL 38.45 mL
2.5 mM 0.77 mL 3.85 mL 7.69 mL
5 mM 0.38 mL 1.92 mL 3.85 mL
25 mM 0.08 mL 0.38 mL 0.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for IKK 16

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for IKK 16

For research use only

Customer Reviews for IKK 16 (1)

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  • IKK 16 blocks LPA-mediated COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    Human osteosarcoma cells were incubated with 5 μM IKK 16 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. IKK 16 abolished LPA-induced COX-2 expression
    IKK 16 2539

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