Selective inhibitor of Iκ
B kinase (IKK) (IC50
values are 40, 70 and 200 nM for IKKβ
, IKK complex and IKKα
respectively). Inhibits TNF-α
B degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50
values are 1.0, 0.5, 0.3 and 0.3 μ
M respectively). Inhibits LPS-induced TNF-α
release in vivo
and neutrophil extravasion in thioglycollate-induced peritonitis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK.
Waelchli et al.
The citations listed below are publications that use Tocris products. Selected citations for IKK 16 include:
Showing Results 1 - 3 of 3