IL-12 p70/IL-12A Antibody

Novus Biologicals | Catalog # NBP2-24627

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (95%), Monkey (100%), Mouse (95%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all IL-12 p70 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 200-219 of IL-12A was used as the immunogen for this antibody.

Reactivity Notes

Predicted to react with goat, pig.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-12 p70/IL-12A Antibody

Western Blot: IL-12 p70/IL-12A Antibody [NBP2-24627]

Western Blot: IL-12 p70/IL-12A Antibody [NBP2-24627]

Western Blot: IL-12 p70/IL-12A Antibody [NBP2-24627] - Analysis of IL-12A in recombinant IL-35 using IL-12A antibody at 4 ug/ml.

Applications for IL-12 p70/IL-12A Antibody

Application
Recommended Usage

Western Blot

3-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-12 p70

Interleukin-12, or IL-12, also known as natural killer cell stimulatory factor (NKSF) and cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine that affects both natural killer (NK) cells and T lymphocytes. IL-12 is a heterodimer of subunit IL-12A p35 and subunit IL-12B p40 that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. It is involved in mediating many aspects of antiviral immunity. In addition to stimulating T helper cell development, IL-12 is a potent inducer of interferon-gamma (IFN-gamma) production by T cells and NK cells. Increased IL-12 production is a consequence of EBV, CMV, LCMV or HSV infection. While it is unclear what separate effects can be attributed to each IL-12 subunit, evidence suggests IL-12A p35 is the biologically active component responsible for signal transduction via the IL-12 receptor.

Long Name

Interleukin 12 p70

Alternate Names

IL12 p70

Gene Symbol

IL12A

Additional IL-12 p70 Products

Product Documents for IL-12 p70/IL-12A Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for IL-12 p70/IL-12A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for IL-12 p70/IL-12A Antibody

Showing  1 - 2 of 2 FAQs Showing All

  • Q:

    Does the human IL-12 polyclonal antibody (Catalog # AB-219-NA) recognize IL-12 p70?

    A: In Western blots, this antibody recognizes the p70 heterodimer as well as the p40 and p35 subunits.

  • Q: May I request a copy of the WB protocol that was used to generate the WB image presented on the data sheet for NBP2-24627 (IL12A Antibody)?

    A: This image was obtained using our standard Western blot protocol with the antibody used at a concentration of 4ug/mL.

  • Q:

    Does the human IL-12 polyclonal antibody (Catalog # AB-219-NA) recognize IL-12 p70?

    A: In Western blots, this antibody recognizes the p70 heterodimer as well as the p40 and p35 subunits.

  • Q: May I request a copy of the WB protocol that was used to generate the WB image presented on the data sheet for NBP2-24627 (IL12A Antibody)?

    A: This image was obtained using our standard Western blot protocol with the antibody used at a concentration of 4ug/mL.

Showing  1 - 2 of 2 FAQs Showing All
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