IL-12 R beta 1 Antibody

Name: IL-12 R beta 1 Antibody
Brand: Novus Biologicals
SKU: NBP1-49875
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-49875

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-HVSVKNHSLDSVS corresponding to internal region according to NP_005526.1.

Epitope

HVSVKNHSLDSVS - Internal region

Specificity

This antibody is expected to recognize isoform 1 (NP_005526.1) only.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for IL-12 R beta 1 Antibody

Western Blot: IL-12 R beta 1 Antibody [NBP1-49875]

Western Blot: IL-12 R beta 1 Antibody [NBP1-49875] - Analysis of IL12RB1 in Peripharal Blood Lymphocytes lysate (35ug protein in RIPA buffer) using NBP1-49875 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for IL-12 R beta 1 Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

0.3 - 1 ug/ml

Application Notes

WB: Approx. 100 kDa band observed in human peripheral blood mononucleocytes lysates (calculated MW of 73.1 kDa band according to NP_005526.1). The observed molecular weight corresponds to the glycosylated form.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-12 R beta 1

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Long Name

Interleukin 12 Receptor beta 1

Alternate Names

CD212, IL-12Rb1, IL12R beta 1, IL12RB1

Entrez Gene IDs

3594 (Human)

Gene Symbol

IL12RB1

UniProt

NP_005526.1 (Human)

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Product Specific Notices for IL-12 R beta 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.