IL12B Antibody

Novus Biologicals | Catalog # NB100-61661

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all IL12B Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QGKSKREKKDRVFTD corresponding to internal region according to NP_002178.2.

Epitope

QGKSKREKKDRVFTD

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for IL12B Antibody

Western Blot: IL12B Antibody [NB100-61661]

Western Blot: IL12B Antibody [NB100-61661]

Western Blot: IL12B Antibody [NB100-61661] - (0.3ug/ml) staining of Human Liver (A), Skin (B) and Tonsil (C) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for IL12B Antibody

Application
Recommended Usage

Peptide ELISA

detection limit 1:16000

Western Blot

0.1ug/ml
Application Notes
WB: Approx. 37 kDa band observed in human liver lysates (calculated MW of 37.2 kDa band according to NP_002178.2).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL12B

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Over expression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternate Names

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2IL12, subunit p40

Entrez Gene IDs

3593 (Human)

Gene Symbol

IL12B

UniProt

NP_002178.2 (Human)

Additional IL12B Products

Product Documents for IL12B Antibody

Certificate of Analysis

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Product Specific Notices for IL12B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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