Potent and selective v-Abl tyrosine kinase inhibitor (IC50
= 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl
-transformed PB-3 cells and v-sis
-transformed BALB/c 3T3 cells in vitro
. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis
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All Tocris products are intended for laboratory research use only.
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
Buchdunger et al.
Cancer Res., 1996;56:100
Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.
Juurikivi et al.