Catalog Number: 2611
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Biological Activity
Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1�and breast cancer cells.
Technical Data
  • M.Wt:
    383.67
  • Formula:
    C15H8ClF6NO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    978-62-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.
    Onai et al.
    Cardiovasc.Res., 2004;63:51
  2. A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.
    Tanaka et al.
    Cancer Res., 2006;66:419
  3. A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors.
    Tanaka et al.
    Hematopoiesis, 2005;105:2324
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IMD 0354 include:

3 Citations: Showing 1 - 3
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  1. Tumor-suppressive microRNA-497 targets IKKβ to regulate NF-κB signaling pathway in human prostate cancer cells.
    Authors: Kong Et al.
    Am J Cancer Res 2015;5:1795
  2. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    J Mol Neurosci 2015;21:276
  3. Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
    Authors: Zwicker Et al.
    Clin Sci (Lond) 2015;129:281

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