IMD 0354

Catalog # Availability Size / Price Qty
2611/10
2611/50
IMD 0354 | CAS No. 978-62-1 | IkB Kinase Inhibitors
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Description: Inhibitor of IKKβ; also exhibits antibacterial activity

Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Purity: ≥99%

Product Details
Citations (6)
Reviews

Biological Activity

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Also antagonist at P2X1, P2X4 and P2X7 receptors (IC50 values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collegen in vitro. Also exhibits potent antibacterial activity against MRSA in C. elegans model (MIC = 0.06 μg/mL).

Technical Data

M.Wt:
383.67
Formula:
C15H8ClF6NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
978-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.
    Onai et al.
    Cardiovasc.Res., 2004;63:51
  2. A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.
    Tanaka et al.
    Cancer Res., 2006;66:419
  3. A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors.
    Tanaka et al.
    Hematopoiesis, 2005;105:2324
  4. New antimicrobial bioactivity against multidrug resistant gram-positive bacteria of kinase inhibitor IMD0354.
    Escobar et al.
    Antibiotics, 2020;9:665

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