IMD 0354

  ( 4 citations )    
Product Datasheet
Catalog Number:2611
Chemical Name:N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Product Details
Citations (4)
Reviews
Biological Activity
Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells.
Technical Data
  • M.Wt:
    383.67
  • Formula:
    C15H8ClF6NO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    978-62-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IMD 0354 include:

4 Citations: Showing 1 - 4
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  1. Tumor-suppressive microRNA-497 targets IKKβ to regulate NF-κB signaling pathway in human prostate cancer cells.
    Authors: Kong Et al.
    Am J Cancer Res  2015;5:1795
  2. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
    Authors: Cataldi Et al.
    Virology  2015;485:340
  3. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    J Mol Neurosci  2015;21:276
  4. Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
    Authors: Zwicker Et al.
    Clin Sci (Lond)  2015;129:281

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