Indisulam

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6782/5
6782/25
Indisulam | CAS No. 165668-41-7 | Ubiquitin Ligase (E3) Inhibitors
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Description: Molecular glue; pre-mRNA splicing modulator

Chemical Name: N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39 (also designated CAPERα, HCC1, FSAP59, and RNPC2), via binding to DCAF15. Acts as a pre-mRNA splicing modulator (SPLAMs; splicing inhibitor sulfonamides), causes aberrant pre-mRNA splicing. Suppresses proliferation of cancer cell lines. Reduces viability of HCT-116 cells (IC50 = 0.56 μM). Induces cell cycle arrest in the G1 phase in cancer cell lines. Also a high affinity carbonic anhydrase isozyme XII (hCA XII) inhibitor (Ki = 3.0-5.7 nM).

Technical Data

M.Wt:
385.84
Formula:
C14H12ClN3O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
165668-41-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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