Indomethacin (CAS 53-86-1): R&D Systems
Catalog Number: 1708
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Biological Activity
Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
Technical Data
  • M.Wt:
    357.79
  • Formula:
    C19H16ClNO4
  • Solubility:
    Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    53-86-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
    Palomer et al.
    J.Med.Chem., 2002;45:1402
  2. Chemical and biological studies on indomethacin, sulindac and their analogs.
    Shen and Winter
    Adv.Drug Res., 1977;12:90
  3. Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool.
    Walters and Willoughby
    J.Pathol.Bacteriol., 1965;90:641
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Indomethacin include:

5 Citations: Showing 1 - 5
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  1. Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
    Authors: Gonnermann Et al.
    Oncoimmunology 2015;4:e988460
  2. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    J Biomed Sci 2015;35:5664
  3. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun 2014;5:3284
  4. Multiscale prediction of patient-specific platelet function under flow.
    Authors: Flamm Et al.
    Blood 2012;120:190
  5. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
    Authors: Miller Et al.
    Proc Natl Acad Sci U S A 2012;109:20602

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