Indomethacin

Key Product Details

Product Description

Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC₅₀ values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

Product Specifications for Indomethacin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Indomethacin

The following data is based on the product molecular weight 357.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

• Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
• Shen and Winter Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 1977 PMID: 343530
• Walters and Willoughby Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 1965 PMID: 5849618
• Palomer Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 2002 PMID: 11906281

Product Documents for Indomethacin