Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Biological ActivityCyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
Palomer et al.
Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool.
Walters and Willoughby
Chemical and biological studies on indomethacin, sul. and their analogs.
Shen and Winter
Adv.Drug Res., 1977;12:90
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
Citations for Indomethacin
The citations listed below are publications that use Tocris products. Selected citations for Indomethacin include:
6 Citations: Showing 1 - 6
DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
Authors: Allen Et al.
Front Oncol 2015;5:260
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
Authors: Gonnermann Et al.
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
J Biomed Sci 2015;35:5664
Lactate-mediated glia-neuronal signalling in the mammalian brain.
Authors: Tang Et al.
Nat Commun 2014;5:3284
Multiscale prediction of patient-specific platelet function under flow.
Authors: Flamm Et al.
CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
Authors: Miller Et al.
Proc Natl Acad Sci U S A 2012;109:20602
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