INF 4E

Tocris Bioscience | Catalog # 6172

Caspase-1 and NLRP3 inflammasome inhibitor
Tocris Bioscience

Key Product Details

Description

Caspase-1 and NLRP3 inflammasome inhibitor
View all Inflammasomes Inhibitors »

Product Description

INF 4E is a NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

Product Specifications for INF 4E

Molecular Weight

240.68

Formula

C12H13ClO3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate

CAS Number

88039-46-7

PubChem ID

11402215

InChI Key

BSRPDXCMAOIUOO-UHFFFAOYSA-N

SMILES

CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

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Background References

References are publications that support the biological activity of the product.

Product Documents for INF 4E

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for INF 4E

For research use only

Customer Reviews for INF 4E (1)

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  • The inhibitor can inhibit NLRP3 inflammasomes and block IL-1b production
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: THP-1
    Verified Customer | Posted 09/15/2020
    We used this product to study whether bacterial component can induce NLRP3-mediated IL-1beta production. To confirm whether this inhibitor works well, we pretreated THP-1 cells with the inhibitor for 1 h, followed by treatment with LPS+ATP for 2 h. The production of IL-1b in culture supernatant was measured by IL-1b ELISA kit. We showed that this inhibitor can significantly inhibit LPS/ATP-induced IL-1b production.
    INF 4E 6172

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