ATP disodium salt
Chemical Name: Adenosine 5'-triphosphate disodium salt
Biological ActivityP2 purinoceptor agonist.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Extracellular ATP: effects, sources and fate.
Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein.
Guilbert et al.
Historical review: ATP as a neurotransmitter.
Burnstock and Kenned
Trends Pharm.Sci., 2006;27:16
Citations for ATP disodium salt
The citations listed below are publications that use Tocris products. Selected citations for ATP disodium salt include:
3 Citations: Showing 1 - 3
Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling.
Authors: Taheri Et al.
Front Syst Neurosci 2017;11:79
Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury.
Authors: Song Et al.
Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
Authors: Hannedouche Et al.
Purinergic Signal 2013;288:27434
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Reviews for ATP disodium salt
Average Rating: 5 (Based on 5 Reviews)
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I used it to prepare a complex at 1mM concentration.
Used this ATP for kinase assays with IRAK4 and a TAK1 inhibitor to determine Km and Vmax. Worked well with no issues and can freeze thaw with no issues.
I used this product for a kinase assay to look at enzyme kinetics. Worked great and was pure with no issues on solubility or contamination.
RAW macrophages were incubated with ATP (5 mM) for 4 h to follow IL-1b mRNA expression using qPCR. ATP treatment induced inflammatory signalling in macrophages most likely via P2 receptor.
ATP, as expected, activates multiple P2 receptor responses, in cell culture and in brain slices.