Inhibin alpha Antibody (MSVA-561R)

Novus Biologicals | Catalog # NBP3-57218

Recombinant Monoclonal Antibody
Novus Biologicals

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # MSVA-561R
View all Inhibin A Primary Antibodies »

Product Specifications

Immunogen

Recombinant fragment of human Inhibin alpha protein (around aa 233-362) (exact sequence is proprietary) Swissprot P05111

Localization

Cytoplasmic

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is highly specific and optimized for use in Immunohistochemistry.

It has been validated on TMAs covering 76 normal tissues and numerous cancer tissues.

The antibody concentration is optimized for dilution within dilution range using commercially available antibody diluent for immunohistochemistry.

Positive Control
Postive control:Adrenal gland: A moderate to strong INHA positivity should be seen in adrenocortical cells..

Negative Control
Negitve control:Colon: INHA immunostaining should be completely absent.

Storage
Antibody can be stored at 4degC. For extended storage, aliquot and store at -20degC. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Inhibin alpha Antibody (MSVA-561R)

Inhibin alpha Antibody (MSVA-561R)

Immunohistochemistry-Paraffin:Inhibin alpha Antibody (MSVA-561R)NBP3-57218

Strong inhibin alpha immunostaining in all cells of an adrenocortical adenoma.
Inhibin alpha Antibody (MSVA-561R)

Immunohistochemistry-Paraffin:Inhibin alpha Antibody (MSVA-561R)NBP3-57218

A strong inhibin alpha immunostaining is seen in the cyto and syncytiotrophoblast of the placenta of the first trimenon.
Inhibin alpha Antibody (MSVA-561R)

Immunohistochemistry-Paraffin:Inhibin alpha Antibody (MSVA-561R)NBP3-57218

The strongest inhibin alpha immunostaining among normal tissues is seen in the corpus luteum of the ovary.

Applications for Inhibin alpha Antibody (MSVA-561R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:75 1:150
Application Notes
Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121C in pH 7,8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:50 at 37C for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer's directions.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS

Preservative

<0.1% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Inhibin A

INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha),which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Alternate Names

INHA, Inhibin A

Gene Symbol

INHA

Additional Inhibin A Products

Product Documents for Inhibin alpha Antibody (MSVA-561R)

Certificate of Analysis

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Product Specific Notices for Inhibin alpha Antibody (MSVA-561R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Activin Family

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Protocols

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