Insulin Receptor beta Antibody - BSA Free

Novus Biologicals | Catalog # NB120-10991

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Primate

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Insulin Receptor beta Primary Antibodies »

Product Specifications

Immunogen

Protein corresponding to the last 100 C-terminal amino acid residues of the human insulin receptor beta chain. NCBI accession no. NP_000199.

Epitope

C-terminus

Reactivity Notes

Chimpanzee.

Localization

Type I membrane protein.

Specificity

Insulin Receptor beta

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Insulin Receptor beta Antibody - BSA Free

Western Blot: Insulin Receptor beta Antibody [NB120-10991]

Western Blot: Insulin Receptor beta Antibody [NB120-10991]

Western Blot: Insulin Receptor beta Antibody [NB120-10991] - Representative lot data. Human brain lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Insulin Receptor, b subunit (1:1,000). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Insulin Receptor, b subunit (~97kDa)
Immunoprecipitation: Insulin Receptor beta Antibody [NB120-10991]

Immunoprecipitation: Insulin Receptor beta Antibody [NB120-10991]

Immunoprecipitation: Insulin Receptor beta Antibody [NB120-10991] - Immunoprecipitation 10 ug of this antibody immunoprecipitated a-Insulin Receptor, Beta subunit from 500 micrograms of Hek293 cell lysate using protein A agarose beads. Arrow indicates a-Insulin Receptor, Beta subunit (97 kDa).

Applications for Insulin Receptor beta Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:100 - 1:500

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.1 M Tris-Glycine (pH 7.4), 0.15 M NaCl, 30% Glycerol

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Insulin Receptor beta

The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

Alternate Names

CD220, CD220 antigen, EC 2.7.10, EC 2.7.10.1, HHF5, insulin receptor, IR

Entrez Gene IDs

3643 (Human)

Gene Symbol

INSR

Additional Insulin Receptor beta Products

Product Documents for Insulin Receptor beta Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Insulin Receptor beta Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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