IRAK1 Antibody

Novus Biologicals | Catalog # NB100-56699

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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all IRAK1 Primary Antibodies »

Product Specifications

Immunogen

Rabbit anti-IRAK polyclonal antibody was raised against a peptide corresponding to amino acids 700 to 712 of human IRAK.

Specificity

Has no cross reactivity to IRAK2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IRAK1 Antibody

Western Blot: IRAK1 Antibody [NB100-56699]

Western Blot: IRAK1 Antibody [NB100-56699]

Western Blot: IRAK1 Antibody [NB100-56699] - IRAK Antibody [NB100-56699] - Analysis of IRAK-1 in 1) human HeLa and 2) mouse NIH3T3 lysate using IRAK-1 antibody at 1 ug/ml.

Applications for IRAK1 Antibody

Application
Recommended Usage

Immunoprecipitation

2-4 ug per sample

Western Blot

1 - 5 ug/ml
Application Notes
An 80 kDa band is observed.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IRAK1

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (3,4). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (2). IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).

Long Name

Interleukin-1 Receptor-Associated Kinase 1

Alternate Names

Il1rak, Pelle, Plpk

Entrez Gene IDs

3654 (Human); 16179 (Mouse)

Gene Symbol

IRAK1

UniProt

P51617 (Human)

Additional IRAK1 Products

Product Documents for IRAK1 Antibody

Certificate of Analysis

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Product Specific Notices for IRAK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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