ISO 1

Catalog # Availability Size / Price Qty
4288/10
4288/50
Cat.No. 4288 - ISO 1 | C12H13NO4 | CAS No. 478336-92-4
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Description: Macrophage migration inhibitory factor (MIF) inhibitor

Chemical Name: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Macrophage migration inhibitory factor (MIF) inhibitor (IC50 = 7 μM); inhibits MIF tautomerase activity in vitro and in vivo. Protective against mouse models of streptozotocin-induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

Technical Data

M.Wt:
235.24
Formula:
C12H13NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
478336-92-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for ISO 1

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