Potent and selective L-type voltage-gated Ca2+
channel blocker. EC50
values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+
-induced contractions of rabbit aorta respectively; EC25
= 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo
, exerting primary effects on vascular tissue with secondary negative chronotropic action.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.
Hof et al.
Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart.
Wada et al.
Pharmacology of the calcium antagonist isradipine.
Ruegg and Hof
The citations listed below are publications that use Tocris products. Selected citations for Isradipine include:
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