Catalog Number: 4439
Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Biological Activity
Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting native adult heart progenitors with cardiogenic small molecules.
    Russell et al.
    ACS Chem.Biol., 2012;7:1067
  2. A small molecule differentiation inducer increases insulin production by pancreatic β cells.
    Dioum et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:20713
  3. Small-molecule activation of neuronal cell fate.
    Schneider et al.
    Nat.Chem.Biol, 2008;4:408
  4. Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
    Zhang et al.
    Differentiation, 2011;81:233
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