Neurogenic agent. Mediates neuroD
reporter gene induction via activation of Ca2+
influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro
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Targeting native adult heart progenitors with cardiogenic small molecules.
Russell et al.
ACS Chem.Biol., 2012;7:1067
A small molecule differentiation inducer increases insulin production by pancreatic β cells.
Dioum et al.
Small-molecule activation of neuronal cell fate.
Schneider et al.
Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
Zhang et al.