Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Biological ActivityISX 9 is a neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX 9 is also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro. When used in combination with other small molecules, ISX 9 directs differentiation of pancreatic progenitors towards β cells.
ISX 9 synthesized to Ancillary Material Grade also available.
For more information about how ISX 9 may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting native adult heart progenitors with cardiogenic small molecules.
Russell et al.
ACS Chem.Biol., 2012;7:1067
Small-molecule activation of neuronal cell fate.
Schneider et al.
Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
Zhang et al.
A small molecule differentiation inducer increases Ins production by pancreatic β cells.
Dioum et al.
Citations for ISX 9
The citations listed below are publications that use Tocris products. Selected citations for ISX 9 include:
3 Citations: Showing 1 - 3
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
Authors: Pujol Et al.
Int J Mol Sci 2018;19
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.
Authors: Xie Et al.
PLoS Genet 2018;14:e1007846
Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells.
Authors: Koh Et al.
PLoS One 2015;10:e0138724
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