Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Biological ActivityNeurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting native adult heart progenitors with cardiogenic small molecules.
Russell et al.
ACS Chem.Biol., 2012;7:1067
Small-molecule activation of neuronal cell fate.
Schneider et al.
A small molecule differentiation inducer increases Ins production by pancreatic β cells.
Dioum et al.
Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
Zhang et al.
Citations for ISX 9
The citations listed below are publications that use Tocris products. Selected citations for ISX 9 include:
3 Citations: Showing 1 - 3
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
Authors: Pujol Et al.
Int J Mol Sci 2018;19
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.
Authors: Xie Et al.
PLoS Genet 2018;14:e1007846
Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells.
Authors: Koh Et al.
PLoS One 2015;10:e0138724
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