ITE

Key Product Details

Product Description

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (K_i = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Product Specifications for ITE

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ITE

The following data is based on the product molecular weight 286.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.93 mL
5 mM	0.70 mL	3.49 mL	6.99 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Wang An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 2013 PMID: 23851185
• Lehmann The aryl hydrocarbon receptor ligand ITE inhibits TGF beta 1-induced human myofibroblast differentiation. Am.J.Pathol. 2011 PMID: 21406171
• Cheng Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 2015 PMID: 26059097
• Song A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12409613

Product Documents for ITE