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Product Datasheet
Catalog Number:1803
Alternate Names:Aryl hydrocarbon receptor ligand
Chemical Name:2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Product Details
Citations (7)
Reviews
Biological Activity
Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.
Technical Data
  • M.Wt:
    286.3
  • Formula:
    C14H10N2O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    448906-42-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license, US Patent Application 2002183524
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