Catalog Number: 1803
Alternate Names: Aryl hydrocarbon receptor ligand
Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Biological Activity
Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license, US Patent Application 2002183524
Background References
  1. A ligand for the aryl hydrocarbon receptor isolated from lung.
    Song et al.
    Proc.Natl.Acad.Sci.U.S.A., 2002;99:14694
  2. The aryl hydrocarbon receptor ligand ITE inhibits TGF�1-induced human myofibroblast differentiation.
    Lehmann et al.
    Am.J.Pathol., 2011;178:1556
  3. Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.
    Cheng et al.
    Nat.Commun., 2015;6:7209
  4. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
    Wang et al.
    Cancer Lett., 2013;340:63

The citations listed below are publications that use Tocris products. Selected citations for ITE include:

4 Citations: Showing 1 - 4
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  1. ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.
    Authors: Wu Et al.
    PLoS One 2014;9:e86549
  2. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.
    Authors: Nugent Et al.
    PLoS One 2013;54:7463
  3. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
    Authors: Wang Et al.
    Cancer Lett 2013;340:63
  4. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
    Authors: Yeste Et al.
    Proc Natl Acad Sci U S A 2012;109:11270

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