ITE

Catalog # Availability Size / Price Qty
1803/10
ITE | CAS No. 448906-42-1 | Aryl Hydrocarbon Receptor Agonists
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Description: Endogenous agonist for the transcription factor aryl hydrocarbon receptor
Alternative Names: Aryl hydrocarbon receptor ligand

Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (9)
Reviews

Biological Activity

Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Technical Data

M.Wt:
286.3
Formula:
C14H10N2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
448906-42-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license, US Patent Application 2002183524

Product Datasheets

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Citations for ITE

The citations listed below are publications that use Tocris products. Selected citations for ITE include:

9 Citations: Showing 1 - 9

  1. Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.
    Authors: Boule
    Sci Rep  2018;8(1):1826
  2. Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of uminal muscle-invasive bladder cancers.
    Authors: Baker Et al.
    Mol Carcinog  2018;57:606
  3. Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
    Authors: Iyer Et al.
    Cell  2018;173:1123
  4. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.
    Authors: Fusco Et al.
    Front Microbiol  2017;8:240
  5. ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.
    Authors: Wu Et al.
    PLoS One  2014;9:e86549
  6. Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease.
    Authors: Wang Et al.
    Mediators Inflamm  2014;2014:195094
  7. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.
    Authors: Nugent Et al.
    PLoS One  2013;54:7463
  8. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
    Authors: Wang Et al.
    Cancer Lett  2013;340:63
  9. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
    Authors: Yeste Et al.
    Proc Natl Acad Sci U S A  2012;109:11270

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