Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Biological Activity Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.
Soluble to 100 mM in DMSO
Store at RT
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Sold under license, US Patent Application 2002183524
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