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ITE | CAS No. 448906-42-1 | Aryl Hydrocarbon Receptor Agonists
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Description: Endogenous agonist for the transcription factor aryl hydrocarbon receptor
Alternative Names: Aryl hydrocarbon receptor ligand

Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (9)

Biological Activity

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ITE

The citations listed below are publications that use Tocris products. Selected citations for ITE include:

9 Citations: Showing 1 - 9

  1. Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.
    Authors: Boule
    Sci Rep  2018;8(1):1826
  2. Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.
    Authors: Baker Et al.
    Mol Carcinog  2018;57:606
  3. Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
    Authors: Iyer Et al.
    Cell  2018;173:1123
  4. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.
    Authors: Fusco Et al.
    Front Microbiol  2017;8:240
  5. ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.
    Authors: Wu Et al.
    PLoS One  2014;9:e86549
  6. Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease.
    Authors: Wang Et al.
    Mediators Inflamm  2014;2014:195094
  7. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.
    Authors: Nugent Et al.
    PLoS One  2013;54:7463
  8. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
    Authors: Wang Et al.
    Cancer Lett  2013;340:63
  9. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
    Authors: Yeste Et al.
    Proc Natl Acad Sci U S A  2012;109:11270


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