Jasplakinolide

  ( 5 citations )    
Product Datasheet
Catalog Number:2792
Chemical Name:Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Product Details
Citations (5)
Reviews
Biological Activity
Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.
Technical Data
  • M.Wt:
    709.67
  • Formula:
    C36H45BrN4O6
  • Solubility:
    Soluble to 2 mg/ml in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    102396-24-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:

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  1. Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
    Authors: Galvez Et al.
    Neuropharmacology  2016;105:378
  2. Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
    Authors: Turczynska Et al.
    Cell  2015;35:1489
  3. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    PLoS One  2015;160:673
  4. Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
    Authors: LeClaire and Fortwendel
    PLoS One  2015;10:e0142535
  5. Myocardin Family Members Drive Formation of Caveolae.
    Authors: Krawczyk Et al.
    PLoS One  2015;10:e0133931

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