Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Biological ActivityRapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
Effects of jasplakinolide on the kinetics of actin polymerization.
Bubb et al.
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
Bubb et al.
Citations for Jasplakinolide
The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:
5 Citations: Showing 1 - 5
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
Authors: Galvez Et al.
Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
Authors: Turczynska Et al.
Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Authors: Ruprecht Et al.
PLoS One 2015;160:673
Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
Authors: LeClaire and Fortwendel
PLoS One 2015;10:e0142535
Myocardin Family Members Drive Formation of Caveolae.
Authors: Krawczyk Et al.
PLoS One 2015;10:e0133931
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