Jasplakinolide (CAS 102396-24-7): R&D Systems
Catalog Number: 2792
Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Biological Activity
Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.
Technical Data
  • M.Wt:
    709.67
  • Formula:
    C36H45BrN4O6
  • Solubility:
    Soluble to 2 mg/ml in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    102396-24-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
    Cramer
    Curr.Biol., 1999;9:1095
  2. Effects of jasplakinolide on the kinetics of actin polymerization.
    Bubb et al.
    J.Biol.Chem., 2000;275:5163
  3. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
    Bubb et al.
    J.Biol.Chem., 1995;269:14869
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:

4 Citations: Showing 1 - 4
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  1. Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
    Authors: Turczynska Et al.
    Cell 2015;35:1489
  2. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    PLoS One 2015;160:673
  3. Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
    Authors: LeClaire and Fortwendel
    PLoS One 2015;10:e0142535
  4. Myocardin Family Members Drive Formation of Caveolae.
    Authors: Krawczyk Et al.
    PLoS One 2015;10:e0133931

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