Jasplakinolide

Catalog # Availability Size / Price Qty
2792/100U
Cat.No. 2792 - Jasplakinolide | C36H45BrN4O6 | CAS No. 102396-24-7
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Description: Stabilizes F-actin; promotes actin polymerization

Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Product Details
Citations (5)
Reviews

Biological Activity

Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data

Formula:
C36H45BrN4O6
Solubility:
Soluble to 2 mg/ml in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
102396-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for Jasplakinolide

The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:

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