Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Biological ActivityJasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
Bubb et al.
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
Effects of jasplakinolide on the kinetics of actin polymerization.
Bubb et al.
Citations for Jasplakinolide
The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:
10 Citations: Showing 1 - 10
Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines.
Authors: Warchal Et al.
SLAS Discov 2019;24:224
Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy.
Authors: Pfitzer Et al.
Cell Death Dis 2019;10:302
Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP.
Authors: Zhu Et al.
Sci Rep 2018;8:13025
Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
Authors: Neumann Et al.
Dev Cell 2018;45:67
CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex.
Authors: Mordue Et al.
Sci Rep 2017;7:2246
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
Authors: Galvez Et al.
Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
Authors: Turczynska Et al.
Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Authors: Ruprecht Et al.
PLoS One 2015;160:673
Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
Authors: LeClaire and Fortwendel
PLoS One 2015;10:e0142535
Myocardin Family Members Drive Formation of Caveolae.
Authors: Krawczyk Et al.
PLoS One 2015;10:e0133931
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