Jasplakinolide

Catalog # Availability Size / Price Qty
2792/100U
Actin-related Products Small Molecule
1 Image
Description: Stabilizes F-actin; promotes actin polymerization

Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Purity: ≥97%

Product Details
Citations (5)
Reviews

Biological Activity

Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data

M.Wt:
709.67
Formula:
C36H45BrN4O6
Solubility:
Soluble to 2 mg/ml in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
102396-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Jasplakinolide

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5 Citations: Showing 1 - 5

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