Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Biological ActivityRapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
Effects of jasplakinolide on the kinetics of actin polymerization.
Bubb et al.
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
Bubb et al.
Citations for Jasplakinolide
The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:
5 Citations: Showing 1 - 5
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
Authors: Galvez Et al.
Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
Authors: Turczynska Et al.
Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Authors: Ruprecht Et al.
PLoS One 2015;160:673
Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
Authors: LeClaire and Fortwendel
PLoS One 2015;10:e0142535
Myocardin Family Members Drive Formation of Caveolae.
Authors: Krawczyk Et al.
PLoS One 2015;10:e0133931
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