Chemical Name: (7-(Diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-yl)carbamate
Biological ActivityJF-NP-26 is a caged Raseglurant (Cat. No. 4416). Releases raseglurant upon exposure to 405 nm (violet) light. Inhibits the effects of Quisqualate (Cat. No. 0188) in cultured neurons when exposed to 405 nm light. Exhibits analgesic activity in pain models in vivo on photoactivation. Quantum yield = 0.18.
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.
Font et al.
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