Catalog Number: 0188
Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Biological Activity
Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    189.13
  • Formula:
    C5H7N3O5
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 10 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    52809-07-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
    Littman et al.
    Neuropharmacology, 1995;34:829
  2. (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor.
    Porter et al.
    Br.J.Pharmacol., 1992;106:509
  3. Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    Schulte et al.
    Brain Res., 1994;649:203
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-Quisqualic acid include:

8 Citations: Showing 1 - 8
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.
    Authors: Mansari Et al.
    Psychopharmacology (Berl) 2015;232:2343
  3. The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia.
    Authors: Hu and Tu
    Biomed Res Int 2015;2015:831490
  4. Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats.
    Authors: Mansari Et al.
    Int J Neuropsychopharmacol 2015;18
  5. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells.
    Authors: Wall Et al.
    Pigment Cell Melanoma Res 2014;27:263
  6. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
    Authors: Porter Et al.
    J Pharmacol Exp Ther 2005;315:711
  7. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci 2005;25:2245
  8. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
    Authors: Ferré Et al.
    Proc Natl Acad Sci U S A 2002;99:11940

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