L-Quisqualic acid

Catalog # Availability Size / Price Qty
L-Quisqualic acid | CAS No. 52809-07-1 | AMPA Receptor Agonists
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Description: AMPA agonist; also group I mGlu agonist

Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products

Biological Activity

L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

Technical Data

Soluble to 100 mM in 1eq. NaOH and to 10 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-Quisqualic acid

The citations listed below are publications that use Tocris products. Selected citations for L-Quisqualic acid include:

9 Citations: Showing 1 - 9

  1. Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
    Authors: Shin Et al.
    Oncogenesis  2018;7:86
  2. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  3. Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.
    Authors: Mansari Et al.
    Psychopharmacology (Berl)  2015;232:2343
  4. The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia.
    Authors: Hu and Tu
    Biomed Res Int  2015;2015:831490
  5. Restoration of serotonin neuronal firing following long-term administration of bupr. but not parox. in olfactory bulbectomized rats.
    Authors: Mansari Et al.
    Int J Neuropsychopharmacol  2015;18
  6. Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells.
    Authors: Wall Et al.
    Pigment Cell Melanoma Res  2014;27:263
  7. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
    Authors: Porter Et al.
    J Pharmacol Exp Ther  2005;315:711
  8. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245
  9. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
    Authors: Ferré Et al.
    Proc Natl Acad Sci U S A  2002;99:11940


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