Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™
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Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Littman et al.
(S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor.
Porter et al.
Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203
The citations listed below are publications that use Tocris products. Selected citations for L-Quisqualic acid include:
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