Chemical Name: 15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide
Biological ActivityJH-XI-10-02 is a CDK8 Degrader comprising the cereblon binding ligand Pomalidomide (Cat. No. 6302) joined by a linker to a CDK8 inhibitor. JH-XI-10-02 (1 μM) induces significant proteasome-dependent degradation of CDK8 in Jurkat cells after 24 h, with no significant effect on CDK19 levels.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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