JH-XI-10-02

Tocris Bioscience | Catalog # 7304

CDK8 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

CDK8 Degrader (PROTAC®)
View all Active Degraders »

Product Description

JH-XI-10-02 is a CDK8 Degrader (PROTAC®) comprising the cereblon binding ligand Pomalidomide (Cat. No. 6302) joined by a linker to a CDK8 inhibitor. JH-XI-10-02 (1 μM) induces significant proteasome-dependent degradation of CDK8 in Jurkat cells after 24 h, with no significant effect on CDK19 levels.

CDK8 antibody validated for Western Blot also available: Catalog # NBP2-92972.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for JH-XI-10-02

Molecular Weight

920.16

Formula

C53H69N5O9

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide

CAS Number

2209085-22-1

PubChem ID

145708490

InChI Key

JECHBTRAPARMGI-GFTKVEOVSA-N

SMILES

[H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](N(C(CCOCCOCCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)C)CC[C@]34C)[H])[H])[H])C)C8=CC9=C(C=C8)C=CN=C9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.01 50

Preparing Stock Solutions for JH-XI-10-02

The following data is based on the product molecular weight 920.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.17 mL 10.87 mL 21.74 mL
2.5 mM 0.43 mL 2.17 mL 4.35 mL
5 mM 0.22 mL 1.09 mL 2.17 mL
25 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JH-XI-10-02

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JH-XI-10-02

For research use only

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