Chemical Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Biological ActivityReversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson et al.
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
Ghilardi et al.
Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.
Bhattacharya et al.
Citations for JNJ 17203212
The citations listed below are publications that use Tocris products. Selected citations for JNJ 17203212 include:
2 Citations: Showing 1 - 2
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.
Authors: Kelly Et al.
PLoS One 2015;74:252
Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
Authors: Vijayvergiya Et al.
PLoS One 2015;10:e0141366
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for JNJ 17203212
There are currently no reviews for this product. Be the first to review JNJ 17203212 and earn rewards!
Have you used JNJ 17203212?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image