Chemical Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Biological ActivityJNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson et al.
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
Ghilardi et al.
Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.
Bhattacharya et al.
Citations for JNJ 17203212
The citations listed below are publications that use Tocris products. Selected citations for JNJ 17203212 include:
2 Citations: Showing 1 - 2
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.
Authors: Kelly Et al.
PLoS One 2015;74:252
Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
Authors: Vijayvergiya Et al.
PLoS One 2015;10:e0141366
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