Reversible, competitive and potent TRPV1 antagonist (pKi
values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+
-induced channel activation (pIC50
values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo
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All Tocris products are intended for laboratory research use only.
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson et al.
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
Ghilardi et al.
Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.
Bhattacharya et al.
The citations listed below are publications that use Tocris products. Selected citations for JNJ 17203212 include:
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