Cytokine release inhibitor. Inhibits production of IL-1β
, IL-8, IL-6, IL-10 and TNFα
values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro
and prolongs survival in a mouse leukemia model.
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All Tocris products are intended for laboratory research use only.
JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice.
Kakutani et al.
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.
JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
Tajima et al.
Cancer Sci., 2010;101:774