JTE 607 dihydrochloride
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Description: Cytokine release inhibitor; anti-inflammatory
Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Purity: ≥98%
Biological Activity
Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.Technical Data
M.Wt:
597.36
Formula:
C25H31Cl2N3O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
188791-09-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice.
Kakutani et al.
Inflamm.Res., 1999;48:461 -
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.
Jian
Eur.J.Pharmacol., 2004;488:231 -
JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
Tajima et al.
Cancer Sci., 2010;101:774
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