JTE 607 dihydrochloride

Catalog # Availability Size / Price Qty
5185/10
5185/50
JTE 607 dihydrochloride | CAS No. 188791-09-5 | Cytokine Compounds
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Description: Active metabolite binds CPSF3; Pro-drug
Alternative Names: TO-207

Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

JTE 607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

JTE 607 also inhibits cytokine release; it inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.

Technical Data

M.Wt:
597.36
Formula:
C25H31Cl2N3O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
188791-09-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for JTE 607 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for JTE 607 dihydrochloride include:

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