JTE 607 dihydrochloride
1 Image
Description: Cytokine release inhibitor; anti-inflammatory
Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Purity: ≥98%
Biological Activity
Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC 50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.Technical Data
M.Wt:
597.36
Formula:
C25H31Cl2N3O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
188791-09-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice.
Kakutani et al.
Inflamm.Res., 1999;48:461 -
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.
Jian
Eur.J.Pharmacol., 2004;488:231 -
JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
Tajima et al.
Cancer Sci., 2010;101:774
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for JTE 607 dihydrochloride
There are currently no reviews for this product. Be the first to review JTE 607 dihydrochloride and earn rewards!
Have you used JTE 607 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
