JTE 607 dihydrochloride

Catalog # Availability Size / Price Qty
5185/10
5185/50
Cat.No. 5185 - JTE 607 dihydrochloride | C25H31Cl2N3O5.2HCl | CAS No. 188791-09-5
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Description: Cytokine release inhibitor; anti-inflammatory

Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

Technical Data

M.Wt:
597.36
Formula:
C25H31Cl2N3O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
188791-09-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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