Chemical Name: N-[(1Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
Biological ActivityK 22 is a viral RNA synthesis inhibitor; targets membrane-bound coronaviral RNA replication by inhibiting double membrane vesicle (DMV) formation. Inhibits HCoV-229E infection of MRC-5 cells in a plaque forming assay (IC50 = 0.7 μM). Also inhibits HCoV-229E and MERS-CoV replication in human airway epithelia cultures.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus.
Lundin et al.
PLoS Pathog., 2014;10:e1004166
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for K 22
There are currently no reviews for this product. Be the first to review K 22 and earn rewards!
Have you used K 22?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image