K 252a

Key Product Details

Product Description

K 252a is a non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC₅₀ = 32.9 nM), Ca²⁺/calmodulin-stimulated phosphodiesterases (IC₅₀ = 1.3 - 2.9 μM), MLCK (K_i = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

Product Specifications for K 252a

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for K 252a

The following data is based on the product molecular weight 467.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.56 mL	42.78 mL	85.57 mL
1.25 mM	1.71 mL	8.56 mL	17.11 mL
2.5 mM	0.86 mL	4.28 mL	8.56 mL
12.5 mM	0.17 mL	0.86 mL	1.71 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 93 publications citing the usage of this product.

• Ruegg and Burgess Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 1989 PMID: 2672462
• Knusel and Hefti K-252 compounds: modulators of neurotrophin signal transduction. J.Neurochem. 1992 PMID: 1431889
• Morotti K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 2002 PMID: 12118367
• Kase K-252a, a potent inhibitor of protein kinase C from microbial origin. J.Antibiot. 1986 PMID: 3759657

Product Documents for K 252a