K 252a

Catalog # Availability Size / Price Qty
1683/200U
Cat.No. 1683 - K 252a | C27H21N3O5 | CAS No. 99533-80-9
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Description: Protein kinase inhibitor
Alternative Names: SF 2370

Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity

Non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

Technical Data

M.Wt:
467.48
Formula:
C27H21N3O5
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
99533-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for K 252a

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6 Citations: Showing 1 - 6

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