Catalog Number: 1683
Alternate Names: SF 2370
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Biological Activity
Non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. K-252a, a potent inhibitor of protein kinase C from microbial origin.
    Kase et al.
    J.Antibiot., 1986;39:1059
  2. K-252 compounds: modulators of neurotrophin signal transduction.
    Knusel and Hefti
    J.Neurochem., 1992;59:1987
  3. Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
    Ruegg and Burgess
    TiPS, 1989;10:218
  4. K252a inhibits the oncogenic properties of Met, the HGF receptor.
    Morotti et al.
    Oncogene, 2002;21:4885
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