K 252a

  ( 6 citations )    
Product Datasheet
Catalog Number:1683
Alternate Names:SF 2370
Chemical Name:(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).
Technical Data
  • M.Wt:
    467.48
  • Formula:
    C27H21N3O5
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    99533-80-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for K 252a include:

6 Citations: Showing 1 - 6
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  1. Exercise-induced neuroprotection in the spastic Han Wistar rat: the possible role of brain-derived neurotrophic factor.
    Authors: Kummer and Cohen
    Neuropsychopharmacology  2015;2015:834543
  2. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
    Authors: Chen Et al.
    Eur J Neurosci  2014;39:1439
  3. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Biomed Res Int  2014;12:47
  4. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol  2014;128:835
  5. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
    Authors: Park Et al.
    Mol Cells  2013;38:1426
  6. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984

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