Non-selective protein kinase inhibitor; analog of
(Cat.No. 1285). Inhibits PKC (IC
= 32.9 nM), Ca
/calmodulin-stimulated phosphodiesterases (IC
= 1.3 - 2.9
M), MLCK (K
= 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).
27H 21N 3O 5
Soluble to 25 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
K-252a, a potent inhibitor of protein kinase C from microbial origin.
Kase et al.
K-252 compounds: modulators of neurotrophin signal transduction.
Knusel and Hefti
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
Ruegg and Burgess
K252a inhibits the oncogenic properties of Met, the HGF receptor.
Morotti et al.
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