Non-selective protein kinase inhibitor; analog of staurosporine
(Cat.No. 1285). Inhibits PKC (IC50
= 32.9 nM), Ca2+
/calmodulin-stimulated phosphodiesterases (IC50
= 1.3 - 2.9 μ
M), MLCK (Ki
= 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).
Soluble to 25 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
K-252a, a potent inhibitor of protein kinase C from microbial origin.
Kase et al.
K-252 compounds: modulators of neurotrophin signal transduction.
Knusel and Hefti
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
Ruegg and Burgess
K252a inhibits the oncogenic properties of Met, the HGF receptor.
Morotti et al.
The citations listed below are publications that use Tocris products. Selected citations for K 252a include:
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