Potent and highly selective CRF2
receptor antagonist (Ki
values are 0.66, 0.62 and 425 nM for human CRF2α
receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α
- and hCRF2β
-expressing cells. In rats in vivo
, blocks urocortin-induced hypotension following systemic administration.
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Sold with the permission of the Max Planck Institute
Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand.
Ruhmann et al.
The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain.
Lawrence et al.