K 41498

  ( 1 citations )    
Product Datasheet
Catalog Number:2070
Chemical Name:
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
Technical Data
  • M.Wt:
    3632.26
  • Formula:
    C162H276N48O46
  • Sequence:
    FHLLRKXIEIEKQEKEKQQAANNRLLLDTI

    (Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    434938-41-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the Max Planck Institute
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for K 41498 include:

1 Citations: Showing 1 - 1

  1. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
    Authors: Nakamura and Sapru
    Am J Physiol Heart Circ Physiol  2009;296:H2022

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