K 41498

Catalog # Availability Size / Price Qty
2070/1
K 41498
1 Image
Description: Highly selective and potent CRF2 antagonist
Product Details
Citations (1)
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Biological Activity

Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

Technical Data

M.Wt:
3632.26
Formula:
C162H276N48O46
Sequence:
FHLLRKXIEIEKQEKEKQQAANNRLLLDTI

(Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
434938-41-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the Max Planck Institute

Product Datasheets

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Citation for K 41498

The citations listed below are publications that use Tocris products. Selected citations for K 41498 include:

1 Citation: Showing 1 - 1

  1. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
    Authors: Nakamura and Sapru
    Am J Physiol Heart Circ Physiol  2009;296:H2022

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