Biological ActivityK 41498 is a potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
(Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand.
Ruhmann et al.
The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain.
Lawrence et al.
Citation for K 41498
The citations listed below are publications that use Tocris products. Selected citations for K 41498 include:
1 Citation: Showing 1 - 1
Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
Authors: Nakamura and Sapru
Am J Physiol Heart Circ Physiol 2009;296:H2022
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