K34c

Key Product Details

Product Description

K34c is a potent and selective α5β1 integrin inhibitor (IC₅₀ = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

Product Specifications for K34c

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for K34c

The following data is based on the product molecular weight 447.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.17 mL	22.34 mL
5 mM	0.45 mL	2.23 mL	4.47 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

• Kuonen TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 2018 PMID: 29758283
• Martinkova α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 2010 PMID: 20099278
• Renner Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 2016 PMID: 27613837
• Heckmann Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 2007 PMID: 17394271

Product Documents for K34c