Kenpaullone

  ( 2 citations )    
Product Datasheet
Catalog Number:1398
Chemical Name:9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Product Details
Citations (2)
Reviews
Biological Activity
Potent inhibitor of CDK1/cyclin B and GSK-3β (IC50 values are 0.4 and 0.23 μM respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Selective over c-src (IC50 = 15 μM), casein kinase 2 (IC50 = 20 μM), ERK1 (IC50 = 20 μM), ERK2 (IC50 = 9 μM) and a range of other protein kinases (IC50 values > 35 μM). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
Technical Data
  • M.Wt:
    327.18
  • Formula:
    C16H11BrN2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    142273-20-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Kenpaullone include:

2 Citations: Showing 1 - 2
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  1. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat Commun  2015;6:6626
  2. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One  2014;9:e93046

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