Kenpaullone

Key Product Details

Product Description

Kenpaullone is a GSK-3beta inhibitor (IC₅₀ = 0.23 μM). Also inhibits cyclin dependent kinases (cdks) in the sub micromolar range (reported IC₅₀ values are 0.4, 0.68-7 and 0.85 μM for cdk1, cdk2 and cdk5, respectively). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.

Product Specifications for Kenpaullone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Kenpaullone

The following data is based on the product molecular weight 327.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.28 mL	30.56 mL
5 mM	0.61 mL	3.06 mL	6.11 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Lyssiotis Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19447925
• Schultz Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J.Med.Chem. 1999 PMID: 10425100
• Zaharevitz Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 PMID: 10363974
• Buolamwini Cell cycle targets in novel anticancer drug discovery. Curr.Pharm.Des. 2000 PMID: 10788588

Product Documents for Kenpaullone