Catalog Number: 1398
Chemical Name: 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Biological Activity
Potent inhibitor of CDK1/cyclin B and GSK-3β (IC50 values are 0.4 and 0.23 μM respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Selective over c-src (IC50 = 15 μM), casein kinase 2 (IC50 = 20 μM), ERK1 (IC50 = 20 μM), ERK2 (IC50 = 9 μM) and a range of other protein kinases (IC50 values > 35 μM). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cell cycle targets in novel anticancer drug discovery.
    Curr.Pharm.Des., 2000;6:379
  2. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.
    Schultz et al.
    J.Med.Chem., 1999;42:2909
  3. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
    Zaharevitz et al.
    Cancer Res., 1999;59:2566
  4. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.
    Lyssiotis et al.
    Proc.Natl.Acad.Sci.U.S.A., 2009;106:8912

The citations listed below are publications that use Tocris products. Selected citations for Kenpaullone include:

Showing Results 1 - 2 of 2

  1. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat Commun
  2. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One
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