Kisspeptin 10 (human)
Biological ActivityPotent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.
Analog also available.
(Modifications: Phe-10 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Kotani et al.
Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE.
Peilecka-Fortuna et al.
Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors.
Becker et al.
Citations for Kisspeptin 10 (human)
The citations listed below are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:
5 Citations: Showing 1 - 5
Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons.
Authors: Constantin and Wray
Differential stimulation of Ins secretion by GLP-1 and Kisspeptin-10.
Authors: Schwetz Et al.
PLoS One 2014;9:e113020
Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer.
Authors: Ji Et al.
Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver.
Authors: Wu Et al.
Asian-Australas J Anim Sci 2013;26:1080
Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes.
Authors: Wu Et al.
Asian-Australas J Anim Sci 2012;25:1229
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