Potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki
values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Kotani et al.
Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol.
Peilecka-Fortuna et al.
Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors.
Becker et al.
The citations listed below are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:
Showing Results 1 - 4 of 4