Kisspeptin 10 (human)

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Kisspeptin 10 (human)
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Description: Endogenous ligand for kisspeptin receptor
Alternative Names: Metastin (45-54), Kp-10
Product Details
Citations (5)
Supplemental Products

Biological Activity

Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data


(Modifications: Phe-10 = C-terminal amide)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
    Kotani et al.
    J.Biol.Chem., 2001;276:34631
  2. Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE.
    Peilecka-Fortuna et al.
    Endocrinology, 2007;149:1979
  3. Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors.
    Becker et al.
    Biochem.Biophys.Res.Comm., 2005;326:677

Product Datasheets

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Citations for Kisspeptin 10 (human)

The citations listed below are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

5 Citations: Showing 1 - 5


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