Catalog Number: 2570
Alternate Names: Metastin (45-54), Kp-10
Biological Activity
Potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-10 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
    Kotani et al.
    J.Biol.Chem., 2001;276:34631
  2. Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol.
    Peilecka-Fortuna et al.
    Endocrinology, 2007;149:1979
  3. Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors.
    Becker et al.
    Biochem.Biophys.Res.Comm., 2005;326:677

The citations listed below are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10.
    Authors: Schwetz Et al.
    PLoS One 2014;9:e113020
  2. Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer.
    Authors: Ji Et al.
    Autophagy 2014;14:723
  3. Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver.
    Authors: Wu Et al.
    Asian-Australas J Anim Sci 2013;26:1080
  4. Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes.
    Authors: Wu Et al.
    Asian-Australas J Anim Sci 2012;25:1229
Tocris Peptides
Description Application Cat# Citations Images  

Kisspeptin 234

3881 2  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used Kisspeptin 10 (human)?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 


Customer Information