Catalog Number: 1277
Chemical Name: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
Biological Activity
Selective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 μM). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Technical Data
  • M.Wt:
    721.84
  • Formula:
    C38H35N5O6S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    127191-97-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KN-62 include:

15 Citations: Showing 1 - 10
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  1. Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug.
    Authors: Ishii and Sugimura
    Cell Rep 2015;8:42618
  2. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One 2015;85:173
  3. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.
    Authors: Heo Et al.
    Sci Rep 2015;5:16895
  4. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Cell Sci 2015;5:16222
  5. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.
    Authors: Giannuzzo Et al.
    J Chem Biol 2015;14:203
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Sci Rep 2015;10:e0132884
  7. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
    Authors: Oh Et al.
    Neuron 2015;10:162
  8. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res 2012;318:2004
  9. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
    Authors: Trabanelli Et al.
    J Immunol 2012;189:1303
  10. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
    Authors: Mockett Et al.
    J Neurosci 2011;31:7380
  11. Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
    Authors: George Et al.
    J Neurophysiol 2011;106:319
  12. Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei.
    Authors: Person and Raman
    Neuron 2010;66:550
  13. Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP.
    Authors: Kobayashi Et al.
    J Immunol 2010;184:6350
  14. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol 2009;157:1203
  15. Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.
    Authors: Díaz-Hernández Et al.
    Mol Cancer 2008;121:3717
Expand to show all 15 Citations

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