KT 5823

Catalog # Availability Size / Price Qty
1289/100U
KT 5823 | CAS No. 126643-37-6 | Protein Kinase G Inhibitors
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Description: Selective protein kinase G inhibitor

Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

Purity: ≥95%

Product Details
Citations (6)
Reviews

Biological Activity

KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Technical Data

M.Wt:
495.53
Formula:
C29H25N3O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Desiccate at -20°C
CAS No:
126643-37-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis
    K Minami, S Liu, Y Liu, A Chen, Q Wan, S Na, BY Li, N Matsuura, M Koizumi, Y Yin, L Gan, A Xu, J Li, H Nakshatri, H Yokota
    Sci Rep, 2017;7(0):45686.
  2. Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide y on postnatal hippocampal precursor cells.
    Cheung A, Newland PL, Zaben M
    J. Biol. Chem., 2012;287(24):20187-96.
  3. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
    Gadbois et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:8626
  4. Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells.
    Murthy and Makhlouf
    Am.J.Physiol., 1995;268:C171
  5. Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects.
    Smolenski et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:134

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