Catalog Number: 1289
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Biological Activity
Selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
Technical Data
  • M.Wt:
    495.53
  • Formula:
    C29H25N3O5
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    126643-37-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KT 5823 include:

2 Citations: Showing 1 - 2
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  1. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
    Authors: Becker Et al.
    Development 2014;141:335
  2. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats.
    Authors: Giricz Et al.
    J Neurosci 2009;158:1495

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