Promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021
(Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
Soluble to 50 mM in DMSO
Store at +4°C
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A small molecule that promotes cardiac differentiation of humam pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Minami et al.
Cell Rep., 2012;2:1448