Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Biological ActivityKY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Minami et al.
Cell Rep., 2012;2:1448
Citations for KY 02111
The citations listed below are publications that use Tocris products. Selected citations for KY 02111 include:
2 Citations: Showing 1 - 2
Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour.
Authors: Chris Et al.
Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis.
Authors: Qui Et al.
J.Am.Heart Assoc. 2017;6:e005295
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