Kynureninase Antibody (OTI1H1) - Azide and BSA Free

Novus Biologicals | Catalog # NBP2-71400

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # OTI1H1

Format

Azide and BSA Free
View all Kynureninase Primary Antibodies »

Product Specifications

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-216 of human KYNU (NP_001028170) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Theoretical MW

34.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Kynureninase Antibody (OTI1H1) - Azide and BSA Free

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Human thyroid tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Adenocarcinoma of Human breast tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Adenocarcinoma of Human colon tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Adenocarcinoma of Human ovary tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Carcinoma of Human lung tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Carcinoma of Human pancreas tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Human lymph node tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - Analysis of Human pancreas tissue.
Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400]

Immunohistochemistry: Kynureninase Antibody (OTI1H1) - Azide and BSA Free [NBP2-71400] - staining of paraffin-embedded Human lymphoma tissue using anti-KYNU mouse monoclonal antibody. ; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min)

Applications for Kynureninase Antibody (OTI1H1) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:150

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Reconstitution

we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process.

Formulation

Lyophilized from PBS (pH 7.3) with 8% Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Kynureninase

KYNU, also known as Kynureninase, has a 465 amino acid long isoform that is 52 kDa and a short 307 amino acid that is 35 kDa; its highest expressed levels are found in placenta, liver and lung; is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid (Ant), and It can also act on 3hKyn (to produce 3hAnt) and some other (3-arylcarbonyl)-alanines, and has cysteine-conjugate-beta-lyase activity. This protein is currently being studied for research on the following diseases and disorders: transient cerebral ischemia, vitamin b deficiency, hydroxykynureninuria, pellagra, cerebritis, ischemia, atopic dermatitis, intrahepatic cholangiocarcinoma, essential hypertension, noma, brain injury, dermatitis, psoriasis cholangiocarcinoma, neurologic diseases, interferon, and neuronitis. Interactions with KYNU protein have been shown to involve 40 proteins including GCK, PIN1, NEDD4L, HSPA9, and ETFA in tryptophan catabolism, metabolism, metabolism of amino acids and derivatives, and NAD metabolism pathways.

Alternate Names

KYNU, L-kynurenine hydrolase

Gene Symbol

KYNU

Additional Kynureninase Products

Product Documents for Kynureninase Antibody (OTI1H1) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for Kynureninase Antibody (OTI1H1) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Kynurenine Pathway

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Protocols

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FAQs

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