Chemical Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Biological ActivityPotent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Brabet et al.
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells.
Hayashi et al.
Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord.
Shinozaki et al.
Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.
Wright and Schoepp
Citations for L-CCG-l
The citations listed below are publications that use Tocris products. Selected citations for L-CCG-l include:
4 Citations: Showing 1 - 4
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models.
Authors: Han Et al.
Biomed Res Int 2015;2015:893163
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Authors: Ster Et al.
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