Catalog Number: 0333
Alternate Names: (2S,3S,4S)-CCG
Chemical Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Biological Activity
Potent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).
Technical Data
  • M.Wt:
    159.14
  • Formula:
    C6H9NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    117857-93-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
    Brabet et al.
    Neuropharmacology, 1998;37:1043
  2. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells.
    Hayashi et al.
    Br.J.Pharmacol., 1992;107:539
  3. Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.
    Wright and Schoepp
    Eur.J.Pharmacol., 1996;297:275
  4. Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord.
    Shinozaki et al.
    Br.J.Pharmacol., 1989;98:1213
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-CCG-l include:

4 Citations: Showing 1 - 4
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models.
    Authors: Han Et al.
    Biomed Res Int 2015;2015:893163
  3. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  4. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    Neuron 2011;108:9993

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