Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Biological ActivityThalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase.
Petzold et al.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Krönke et al.
Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.
Donovan et al.
Evolution of cereblon-mediated protein degradation as a therapeutic modality.
Chamberlain et al.
ACS Med.Chem.Lett., 2019;10:1592
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