Lipid A Antibody (26-5)

Novus Biologicals | Catalog # NBP3-11256

Novus Biologicals
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Key Product Details

Species Reactivity

Bacteria

Applications

Immunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 26-5
View all Lipid A Primary Antibodies »

Product Specifications

Immunogen

The monoclonal antibody 26-5 recognizes lipid A.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Lipid A Antibody (26-5)

Application
Recommended Usage

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Lipid A

The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria.
Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. The heteropolysaccharide generally consists of an oligosaccharide termed the core region. This core region is in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. The lipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system. Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such as TNF-alpha and IL-1beta. Furthermore, lipid A activates the production of costimulatory molecules required for adaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. All these events are desirable for clearing local infections.

Alternate Names

Lipid A Lipopolysaccharide

Additional Lipid A Products

Product Documents for Lipid A Antibody (26-5)

Certificate of Analysis

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Product Specific Notices for Lipid A Antibody (26-5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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