Potent neuropeptide Y (NPY) Y5
receptor antagonist (Ki
= 1.5 nM in vitro
). Displays ≥ 3300-fold affinity for Y5
receptors. Also binds human 5-HT2B
values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
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All Tocris products are intended for laboratory research use only.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydrobenzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects
Walker et al.