Catalog Number: 3077
Chemical Name: 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Biological Activity
High affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.
Technical Data
  • M.Wt:
    372.89
  • Formula:
    C21H24N2O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    172895-15-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Eli Lilly and company
Background References
  1. In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine2 receptors in rat.
    Sevoz-Couche et al.
    Br.J.Pharmacol., 2000;131:1445
  2. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Niebert et al.
    PLoS One, 2011;6:e21395
  3. LY272015, a potent, selective and orally active 5-HT2B receptor antagonist.
    Cohen et al.
    J.Serotonin Res., 1996;3:131
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 272015 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    PLoS One 2015;3:e00103
  2. Expression of serotonin receptors in human hepatocellular cancer.
    Authors: Soll Et al.
    Clin Cancer Res 2012;18:5902
  3. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Authors: Niebert Et al.
    J Pharmacol Exp Ther 2011;6:e21395

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