LY 272015 hydrochloride

Tocris Bioscience | Catalog # 3077

High affinity 5-HT2B antagonist; orally active
Tocris Bioscience

Key Product Details

Description

High affinity 5-HT2B antagonist; orally active
View all 5-HT2B Receptor Antagonists »

Product Description

LY 272015 hydrochloride is a high affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.

Licensing Information

Sold under license from Eli Lilly and company

Product Specifications for LY 272015 hydrochloride

Molecular Weight

372.89

Formula

C21H24N2O2.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride

CAS Number

172895-15-7

PubChem ID

9929423

InChI Key

BKAZOTIBKRWLQA-UHFFFAOYSA-N

SMILES

CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.29 100
Ethanol 3.73 10

Preparing Stock Solutions for LY 272015 hydrochloride

The following data is based on the product molecular weight 372.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 272015 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 272015 hydrochloride

For research use only

Citations for LY 272015 hydrochloride

Customer Reviews for LY 272015 hydrochloride (1)

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  • 5-HT has a potential for relaxant
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 02/18/2020
    LY272015 (1 lmol/L)
    LY 272015 hydrochloride 3077

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