LY 393558

   
Product Datasheet
Catalog Number:3350
Chemical Name:1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
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Biological Activity
Dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT2A and 5-HT2B receptors (pKi values are 7.29 and 7.35 respectively).
Technical Data
  • M.Wt:
    546.68
  • Formula:
    C26H31FN4O4S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    271780-64-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human 5-HT1B (NP_000854) VersaClone cDNA

RDC0284
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