LY 456236 hydrochloride

Tocris Bioscience | Catalog # 2390

Selective mGlu1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective mGlu1 antagonist

Alternative Names

MPMQ hydrochloride
View all Group I mGluR Antagonists »

Product Description

LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.

Product Specifications for LY 456236 hydrochloride

Molecular Weight

317.77

Formula

C16H15N3O2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride

CAS Number

338736-46-2

PubChem ID

9926998

InChI Key

AVKFOWUSTVWZQN-UHFFFAOYSA-N

SMILES

Cl.COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.36 20

Preparing Stock Solutions for LY 456236 hydrochloride

The following data is based on the product molecular weight 317.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.73 mL 78.67 mL 157.35 mL
1 mM 3.15 mL 15.73 mL 31.47 mL
2 mM 1.57 mL 7.87 mL 15.73 mL
10 mM 0.31 mL 1.57 mL 3.15 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for LY 456236 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 456236 hydrochloride

For research use only

Citations for LY 456236 hydrochloride

Customer Reviews for LY 456236 hydrochloride (1)

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  • Action via NMDA receptors
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 04/02/2021
    Can be easily diluted, no problem with long-time storage in aliquots.
    1 microM LY 456236 was tested on action potentials generated by current injection into CA3 hippocampal neuron. Application of LY increased significantly a number of action potentials. This effect disappeared after partial block of NMDA receptors. Illustration: control recording of action potentials (top) and recording with LY 456236 (bottom).
    LY 456236 hydrochloride 2390

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