receptor antagonist (IC50
values are 143 nM and > 10 μ
M for mGlu1
receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50
values of 28 and 16.3 mg/kg respectively.
Soluble to 20 mM in DMSO
Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.
Shannon et al.
Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects.
Bertorelli et al.