LY 456236 hydrochloride

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2390/10
2390/50
LY 456236 hydrochloride | CAS No. 338736-46-2 | Group I mGluR Antagonists
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Description: Selective mGlu1 antagonist
Alternative Names: MPMQ hydrochloride

Chemical Name: 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride

Purity: ≥99%

Product Details
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Reviews (1)

Biological Activity

LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.

Technical Data

M.Wt:
317.77
Formula:
C16H15N3O2.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
338736-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.
    Shannon et al.
    Neuropharmacology, 2005;49:188
  2. Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects.
    Bertorelli et al.
    Neuropharmacology, 2005;49:231

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Action via NMDA receptors
By Sergiy Sylantyev on 04/02/2021
Application: Species: Mouse

1 microM LY 456236 was tested on action potentials generated by current injection into CA3 hippocampal neuron. Application of LY increased significantly a number of action potentials. This effect disappeared after partial block of NMDA receptors. Illustration: control recording of action potentials (top) and recording with LY 456236 (bottom).


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