LY 456236 hydrochloride

Catalog # Availability Size / Price Qty
LY 456236 hydrochloride | CAS No. 338736-46-2 | Group I mGluR Antagonists
1 Image
Description: Selective mGlu1 antagonist
Alternative Names: MPMQ hydrochloride

Chemical Name: 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride

Purity: ≥99%

Product Details
Supplemental Products

Biological Activity

LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.

Technical Data

Soluble to 20 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.
    Shannon et al.
    Neuropharmacology, 2005;49:188
  2. Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects.
    Bertorelli et al.
    Neuropharmacology, 2005;49:231

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for LY 456236 hydrochloride

There are currently no reviews for this product. Be the first to review LY 456236 hydrochloride and earn rewards!

Have you used LY 456236 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.