Catalog Number: 2390
Alternate Names: MPMQ hydrochloride
Chemical Name: 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride
Biological Activity
Selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.
Technical Data
  • M.Wt:
    317.77
  • Formula:
    C16H15N3O2.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    338736-46-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.
    Shannon et al.
    Neuropharmacology, 2005;49:188
  2. Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects.
    Bertorelli et al.
    Neuropharmacology, 2005;49:231

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