LYK5 Antibody

Novus Biologicals | Catalog # NBP2-24700

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all LYK5 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 300-350 of human STRAD (isoform 1) was used as the immunogen.

Reactivity Notes

The amino acid sequence used is 100% homologous in Yellow Fluorescent Protein (YFP) and Cyan Fluorescent Protein (CFP). The NCBI accession number for GFP is AAC78774. Mouse reactivity reported in scientific literature (PMID: 24345663).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LYK5 Antibody

Western Blot: LYK5 Antibody [NBP2-24700]

Western Blot: LYK5 Antibody [NBP2-24700]

Western Blot: LYK5 Antibody [NBP2-24700] - Analysis of LYK5 in A549 cell lysate in the (A) absence and (B) presence of immunizing peptide using NBP2-24700 at 1 ug/ml.

Applications for LYK5 Antibody

Application
Recommended Usage

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LYK5

The protein encoded by the LYK5 gene contains a STE20-like kinase domain, but lacks several residues that are critical forcatalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex withserine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39,also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has beenshown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcriptvariants encoding different isoforms have been found for this gene. Additional transcript variants have been describedbut their full-length nature is not known. (provided by RefSeq)

Alternate Names

LYK5FLJ90524, NY-BR-96, protein kinase LYK5, Serologically defined breast cancer antigen NY-BR-96, STE20-like pseudokinase, STE20-related adapter protein, STE20-related adaptor protein, STE20-related kinase adapter protein alpha, STE20-related kinase adaptor alpha, Stlk, STRAD alpha, STRADPMSE

Gene Symbol

STRADA

Additional LYK5 Products

Product Documents for LYK5 Antibody

Certificate of Analysis

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Product Specific Notices for LYK5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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