Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Biological Activity Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Store at +4°C
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