CD8, also known as Ly-2 or Leu-2, is a heterodimeric glycoprotein (alpha and beta subunits) that functions in conjunction with the T cell receptor in the recognition of MHC class I/peptide complexes. CD8 alpha is expressed on double positive (CD4+8+) thymocytes and mature CD8+ cytolytic T cells, intraepithelial lymphocytes, some gamma-delta T cells, subsets of thymic and splenic dendritic cells, and peritoneal mast cells. It can form disulfide linked homodimers or heterodimers with CD8 beta. Thymic CD8+ DC express primarily alpha-beta heterodimers, while splenic CD8+ DC primarily express alpha-alpha homodimers. CD8 alpha+ DC can present viral antigenic peptides in complex with MHC I and prime CTL responses.
MagCellect Mouse Naive CD8+ T Cell Isolation Kit
R&D Systems | Catalog # MAGM207
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Key Product Details
Species
Mouse
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Background: CD8
Alternate Names
CD8, CD8A
Entrez Gene IDs
Gene Symbol
CD8A
Additional CD8 Products
Product Documents for MagCellect Mouse Naive CD8+ T Cell Isolation Kit
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for MagCellect Mouse Naive CD8+ T Cell Isolation Kit
For research use only
Citations for MagCellect Mouse Naive CD8+ T Cell Isolation Kit
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FAQs for MagCellect Mouse Naive CD8+ T Cell Isolation Kit
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Q: When using MacCellect Cell Isolation kits (MAGM*** or MAGH***), why is it important to lyse red blood cells before starting the cell isolation protocol?
A: It is important to remove red blood cells before the isolation protocol using MagCellect isolation kits because not doing so can cause a poorer yield of selected cells. Red blood cells become sticky during the incubation protocols and may interfere with the interactions needed for removal of unwanted populations.
