MCH (human, mouse, rat)
Purity: ≥95%
Biological Activity
MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.Technical Data
(Modification: Disulfide bridge: 7-16)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Sailer et al.
Proc.Natl.Acad.Sci.USA, 2001;98:7564
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Citations for MCH (human, mouse, rat)
The citations listed below are publications that use Tocris products. Selected citations for MCH (human, mouse, rat) include:
3 Citations: Showing 1 - 3
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Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.
Authors: Jang
Sci Rep 2018;8(1):707
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The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
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Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors.
Authors: Kim and Han
Exp Neurobiol 2016;25:307
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