MCH (human, mouse, rat)
Biological ActivityPotent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.
(Modifications: Disulfide bridge between 7-16)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Sailer et al.
Citations for MCH (human, mouse, rat)
The citations listed below are publications that use Tocris products. Selected citations for MCH (human, mouse, rat) include:
3 Citations: Showing 1 - 3
Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.
Sci Rep 2018;8(1):707
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors.
Authors: Kim and Han
Exp Neurobiol 2016;25:307
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